Viruses, Free Full-Text
Por um escritor misterioso
Descrição
Nucleus accumbens-associated protein 1 (NAC1) is a transcription co-factor that has been shown to possess multiple roles in stem cell and cancer biology. However, little is known about its roles in regulation of the immune system. In the current study, we observed that expression of NAC1 impacted the survival of CD8+ T cells in vitro. NAC1−/− CD8+ T cells displayed lower metabolism, including reduced glycolysis and oxidative phosphorylation. In vivo, compared with wild-type (WT) mice, NAC1−/− mice produced a lower response to vaccinia virus (VACV) infection, and viral antigen (Ag)-specific CD8+ T cells decreased more slowly. Additionally, we observed that the NAC1−/− mice demonstrated a stronger memory formation of viral Ag-specific CD8+ T cells post-viral infection. Mechanically, we identified that compared with WT CD8+ T cells, the Interferon Regulatory Factor 4 (IRF4), a key transcription factor in T cell development, was highly expressed in NAC1−/− CD8+ T cells, insinuating that IRF4 could be a critical regulatory target of NAC1 in the memory formation of CD8+ T cells. Our results indicate that NAC1 restrains the memory formation of CD8+ T cells by modulating IRF4, and targeting NAC1 may be exploited as a new approach to boosting CD8+ T cell memory.
The Top 10 Worst Computer Viruses in History
How to Tell If You Have a Computer Virus
Frontiers Pandemics Throughout History
5 Best Free Online Virus Scanners & Removers for 2023
Viral inactivation by light, eLight
Images of Influenza Viruses
How to Clean your Phone from Virus
Capsid integrity detection of pathogenic viruses in waters: Recent
Journal of Viral Hepatitis
Frontiers COVID-19: Emergence, Spread, Possible Treatments, and
66,493 Virus Structure Images, Stock Photos, 3D objects, & Vectors
Virus - Wikipedia
Malwarebytes Free: Free Antivirus 2024
Stability of the human gut virome and effect of gluten-free diet
de
por adulto (o preço varia de acordo com o tamanho do grupo)