Cells, Free Full-Text

Por um escritor misterioso

Descrição

Anthracyclines such as doxorubicin are widely used chemotherapy drugs. A common side effect of anthracycline therapy is cardiotoxicity, which can compromise heart function and lead to dilated cardiomyopathy and heart failure. Dexrazoxane and heart failure medications (i.e., beta blockers and drugs targeting the renin–angiotensin system) are prescribed for the primary prevention of cancer therapy-related cardiotoxicity and for the management of cardiac dysfunction and symptoms if they arise during chemotherapy. However, there is a clear need for new therapies to combat the cardiotoxic effects of cancer drugs. Exercise is a cardioprotective stimulus that has recently been shown to improve heart function and prevent functional disability in breast cancer patients undergoing anthracycline chemotherapy. Evidence from preclinical studies supports the use of exercise training to prevent or attenuate the damaging effects of anthracyclines on the cardiovascular system. In this review, we summarise findings from experimental models which provide insight into cellular mechanisms by which exercise may protect the heart from anthracycline-mediated damage, and identify knowledge gaps that require further investigation. Improved understanding of the mechanisms by which exercise protects the heart from anthracyclines may lead to the development of novel therapies to treat cancer therapy-related cardiotoxicity.
Cells, Free Full-Text
THE LIVES OF A CELL : LEWIS THOMAS : Free Download, Borrow, and
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
Cell-free methods to produce structurally intact mammalian
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
Experimental design of upsidedown, upside-up, and cell-free
Cells, Free Full-Text
The dependence of cell-free protein synthesis in E. coli upon
Cells, Free Full-Text
Textile-embedded cell-free biosensors
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
Labile coat: reason for noninfectious cell-free varicella-zoster
Cells, Free Full-Text
Harnessing Extracellular Vesicles for Regenerative Therapy
Cells, Free Full-Text
Mol Imaging Radionucl Ther on X: The Role of a Bone SPECT/CT Scan
Cells, Free Full-Text
JCM, Free Full-Text
Cells, Free Full-Text
Antibodies, Free Full-Text
de por adulto (o preço varia de acordo com o tamanho do grupo)